| 청구기호 |
QH603.M44 D94 2018 |
| 다른형태 서명 |
Dynein mechanics, dysfunction, and disease
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| 판사항 |
Second edition.
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| 형태사항 |
1 online resource
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| 언어 |
English |
| 서지주기 |
Includes bibliographical references and index.
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| 내용 |
Machine generated contents note: Volume 2 -- pt. I Structure and Mechanics of Dynein Motors -- 1. Electron microscopy of isolated dynein complexes and the power stroke mechanism / Ken'ya Furuta -- 1.1. Introduction -- 1.2. Historical background of dyneins -- 1.3. Electron microscopic techniques used in recent dynein research -- 1.4. Properties of dynein molecules revealed by advanced electron microscopic techniques -- 1.5. Force generating mechanism of dynein -- References -- 2. Mechanism and regulation of dynein motors / Andrew P. Carter -- 2.1. Overall architecture of the dynein motor -- 2.2. mechanochemical cycle of the dynein motor -- 2.3. Conformational changes in the AAA+ ring drive the mechanochemical cycle -- 2.4. remodeling of the linker during the mechanochemical cycle -- 2.5. ATP hydrolysis primes the dynein motor for microtubule rebinding and the linker power stroke -- 2.6. Variations of the dynein mechanochemical cycle -- 2.7. How dynein motors walk along the microtubule -- 2.8. Determinants of dynein directionality -- 2.9. Dynein motor activation by cargo binding -- 2.10. Conclusions -- References -- 3. Structural analysis of dynein intermediate and light chains / Amrita Dawn -- 3.1. Introduction -- 3.2. Abbreviated background of light chains -- 3.3. Structure of the apo light chains -- 3.4. Structure of liganded light chains -- 3.5. LC8 and TcTex-1 promiscuity -- 3.6. Light chain isoforms -- 3.7. Mammalian dynein intermediate chains -- 3.8. Molecular model of the light-intermediate chain structure -- 3.9. Light chains and cargo -- 3.10. Posttranslational modifications -- 3.11. role of LC8 and TcTex-1 on dynein -- 3.12. Summary -- References -- 4. Biochemical purification of axonemal and cytoplasmic dyneins / Kazuo Inaba -- 4.1. Introduction -- 4.2. Axonemal dyneins -- 4.3. Cytoplasmic dynein -- 4.4. Storage of dynein -- 4.5. Conclusion and perspective -- Acknowledgments -- References -- 5. Single-molecule dynein motor mechanics in vitro / Ahmet Yildiz -- 5.1. Introduction -- 5.2. mechanochemical cycle of dynein -- 5.3. Processivity of a dynein dimer -- 5.4. Velocity of dynein motors -- 5.5. stepping mechanism -- 5.6. Stepping pattern of the two motor domains -- 5.7. role of the AAA sites in dynein motility -- 5.8. Force generation -- 5.9. mechanism of minus end directionality -- 5.10. Mammalian dynein/dynactin complex -- 5.11. Future directions -- Acknowledgments -- References -- 6. Biophysical properties of dynein in vivo / Steven P. Gross -- 6.1. Motility and regulation of dynein in vitro -- 6.2. Biophysical function of dynein in vivo -- 6.3. Regulation of dynein motility in vivo -- References -- 7. Mechanics of bidirectional cargo transport / William O. Hancock -- 7.1. Introduction -- 7.2. Experimental and computational work to date on bidirectional transport -- 7.3. Models of bidirectional transport -- 7.4. Kinesins involved in bidirectional transport -- 7.5. Dynein properties relevant to bidirectional transport -- 7.6. Roles of MAPs and tubulin PTMs in bidirectional transport -- 7.7. Potential effects of membrane fluidity on bidirectional transport -- 7.8. Concluding thoughts -- References -- 8. Chemical probes for dynein / Tarun M. Kapoor -- 8.1. General approach to inhibiting dynein -- 8.2. Nucleotide-mimetic inhibitors of dynein -- 8.3. Ciliobrevins: cell-permeable small molecule dynein inhibitors -- 8.4. Other approaches that allow fast temporal control over dynein function -- Acknowledgments -- References -- 9. Computational modeling of dynein activity and the generation of flagellar beating waveforms / Jonathan Howard -- 9.1. Introduction -- 9.2. Models for beat control in the flagellum -- 9.3. Theory -- 9.4. Discussion -- A.1. Coefficient equations for the boundary value problem -- A.2. Parameter normalizations -- References -- pt. II Dynein Dysfunction and Disease -- 10. Impacts of virus-mediated manipulation of host Dynein / Andrew J. Mouland -- 10.1. Dynein and viral replication -- 10.2. Kinesins -- 10.3. Innate immunity, the Rabs, Rab7-interacting lysosomal protein, and vesicular transport -- 10.4. Dynein, viruses, and the innate immune response -- 10.5. IFITM3 and VAP-A -- 10.6. Dyneins and nuclear integration of viral DNA -- 10.7. Posttranslationally modified microtubules and Dynein -- 10.8. Emerging viruses and co-opting of Dynein -- Major outstanding questions -- Acknowledgments -- References -- 11. use of mouse models to probe cytoplasmic dynein function / Mike Fainzilber -- 11.1. rationale behind using a genetic approach to study the dynein complex -- 11.2. Different approaches for mouse genetic studies -- 11.3. allelic series of mutations in the cytoplasmic dynein heavy chain gene, Dync1h1 -- 11.4. DYNC1H1 mutations in humans -- 11.5. Dynein light chain and intermediate chain mutants -- 11.6. Dynactin mutant mice -- 11.7. Conclusions -- Acknowledgments -- References -- 12. Cytoplasmic dynein and its regulators in neocortical development and disease / Richard B. Vallee -- 12.1. Neocortical development -- 12.2. role of dynein in radial glia progenitors and interkinetic nuclear migration -- 12.3. Roles for the dynein pathway in postmitotic neuronal precursors -- 12.4. Overview of malformations of cortical development associated with dynein mutations -- 12.5. Lissencephaly associated with LIS1 mutations -- 12.6. Malformations of cortical development associated with DYNC1H1 mutations -- 12.7. NDE1 mutations and the pathogenesis of severe microcephaly -- 12.8. Summary -- Acknowledgments -- References -- 13. Cytoplasmic dynein dysfunction and neurodegenerative disease / Erika L.F. Holzbaur -- 13.1. Introduction -- 13.2. Cytoplasmic dynein function in neurons -- 13.3. Dynein dysfunction in mice -- 13.4. Mutations in dynein and in dynein effectors result in a spectrum of neurodevelopmental and neurodegenerative disease in humans -- 13.5. Dynein dysfunction in the pathogenesis of neurodegenerative disease: ALS, HD, and PD -- 13.6. Conclusions -- References -- 14. Dynein dysfunction as a cause of primary ciliary dyskinesia and other ciliopathies / Heymut Omran -- 14.1. Introduction -- 14.2. Ultrastructure of motile cilia -- 14.3. Outer dynein arms -- 14.4. Inner dynein arms -- 14.5. Ciliopathies -- 14.6. Nodal cilia -- 14.7. Ependymal cilia and hydrocephalus -- 14.8. Sperm flagella and male infertility -- 14.9. Fallopian tubes and female infertility -- 14.10. Primary cilia dyskinesia -- 14.11. Molecular defects affecting outer dynein arm components and docking -- 14.12. Molecular defects affecting cytoplasmic preassembly of dynein arms -- 14.13. Preassembly defects of ODA complex type-2 and DNALI1-associated IDA complexes -- 14.14. Preassembly defects of ODA type-1 and type-2 and DNALI1-associated IDA complexes -- 14.15. Molecular defects affecting the 96-nm axonemal ruler -- 14.16. Molecular defects affecting the nexin-dynein regulatory complex -- 14.17. Molecular defects affecting ciliary beat regulation -- References -- 15. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport dyneins / Hannah M.
Mitchison -- 15.1. Introduction -- 15.2. Role of cilia in skeletal development -- 15.3. Clinical features of skeletal ciliopathies -- 15.4. Cell biological basis of skeletal ciliopathies due to IFT defects -- 15.5. Genetic basis of dynein-based skeletal ciliopathies associated with IFT defects -- 15.6. Human mutations in cytoplasmic IFT dynein-2 genes -- 15.7. Future perspective on clinical spectrum, new clinical models, and therapy -- Acknowledgments -- References -- 16. Ciliary dynein dysfunction caused by chronic alcohol exposure / Maureen Wirschell -- 16.1. Overview -- 16.2. Alcohol and mucociliary function -- 16.3. Alcohol and Chlamydomonas flagella -- 16.4. New questions and future directions -- References -- 17. Dynein-based motility of pathogenic protozoa / Kent L. Hill -- 17.1. Introduction: impact of flagellated protozoan parasites on human health and agriculture -- 17.2. Biology and mechanism of flagellar motility in parasite infections -- 17.3. Final remarks -- Supplementary data -- Acknowledgments -- References -- 18. Dynein axonemal light chain 4: involvement in congenital mirror movement disorder / John B. Vincent -- 18.1. Introduction -- 18.2. Axonemal dynein components: biology and disease -- 18.3. Conclusions -- References -- 19. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologues in male mice? / Stephen H. Pilder -- 19.1. Prevailing models of the genetic and functional basis of phenotypes specific to male mice carrying t-haplotypes during the early years of the genomics era -- 19.2. Properties of t-complex testis expressed-1 -- 19.3. Properties of t-complex testis expressed-2 -- 19.4. Properties of Dnahc8 -- 19.5. Chromosomal deletion analysis modifies Lyon's model -- 19.6. Identification of t-complex distorters -- 19.7. What about dyneins? -- References.
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| 주제 |
Dynein.
Microtubules.
SCIENCE --Life Sciences --Anatomy & Physiology. --bisacsh
Dynein. --fast --(OCoLC)fst00900332
Microtubules. --fast --(OCoLC)fst01020141
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| 보유판 및 특별호 저록 |
Print version: 0128094702 9780128094709 , 959875080
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| ISBN |
9780128097014, 0128097019, 0128094702
, 9780128094709
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| QR CODE |
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